What to know about the new US-Israel attacks on Iran

The strikes came two days after the latest U.S.-Iran talks as Trump had pressured Tehran for a deal to constrain its nuclear program, building up a fleet of American warships in the region. Iran's theocracy also has been struggling with growing dissent following nationwide protests that began over the economy but turned into anti-government ones.

The U.S. military said it was looking into reports of civilians killed in Iran in Saturday's strikes. More than 80 people were reported killed and dozens wounded at a girls’ school in the south, the local governor told Iranian state TV.

Supreme leader's compound was one of the first targets

Israel said it had worked with the U.S. for months to plan the attacks. The U.S. military said targets in Iran included Revolutionary Guard command facilities, air defense capabilities, missile and drone launch sites and military airfields.

One of the first strikes hit near Khamenei's offices. The two Israeli officials who said Israel had confirmed his death both spoke on condition of anonymity pending a formal announcement. There was no immediate comment from the U.S. or Iran on his status.

The 86-year-old Khamenei has ruled since 1989 and holds ultimate power.

Earlier, Iranian Foreign Minister Abbas Araghchi told NBC News that Khamenei and President Masoud Pezeshkian are alive “as far as I know.”

The U.S. and Israel also struck Iran last June during earlier nuclear talks, greatly weakening Iran’s air defenses, military leadership and nuclear program.

The Trump administration has asserted that Iran had been rebuilding its nuclear program, which Tehran has insisted is for peaceful purposes.

Iran strikes back at Israel and U.S. bases

Iran responded Saturday by launching missiles and drones targeting Israel and strikes targeting U.S. military installations in Bahrain, Kuwait and Qatar.

About 12 hours after the attacks began, the U.S. military reported no U.S. casualties and minimal damage at U.S. bases despite “hundreds of Iranian missile and drone attacks.”

Israel’s military said Iran fired “dozens” of missiles at Israel, with many intercepted. Emergency responder Magen David Adom noted 89 “lightly injured” people.

Saudi Arabia said Iran had targeted its capital and eastern region in an attack that was repelled. Bahrain said a missile attack targeted the U.S. Navy’s 5th Fleet headquarters in the island kingdom, and three buildings were damaged in the capital, Manama, and Muharraq city by drone strikes and debris from an intercepted missile.

Kuwait’s civil aviation authority said a drone targeted the main international airport, injuring several employees. Kuwait’s state-run news agency said three troops were injured by shrapnel from strikes that hit Ali Al-Salem air base. Explosions could also be heard in Qatar. Jordan said it “dealt with” 49 drones and ballistic missiles.

Iranian-backed Houthis in Yemen, meanwhile, have vowed to resume attacks on Red Sea shipping routes and on Israel, according to two senior Houthi officials who spoke on condition of anonymity because there was no official announcement from leadership.

Trump tells Iranians it's time to topple their government

In an 8-minute video on social media, Trump announced “major combat operations” and indicated the U.S. was striking for reasons far beyond Iran's nuclear program. He listed grievances stretching back to the beginning of the Islamic Republic following a revolution in 1979 that turned Iran from one of America’s closest allies in the Middle East into a foe.

Trump told Iranians to take cover but urged them to later rise up and topple the Islamic leadership.

“When we are finished, take over your government,” Trump said. “It will be yours to take. This will be probably your only chance for generations.”

The attacks came a day after Trump voiced frustration over lack of progress in negotiations to stop Iran’s ability to develop nuclear weapons.

U.S. military has been building up in the region

The U.S. had assembled a vast fleet of fighter jets and warships in the region to try to pressure Iran into a deal over its nuclear program.

The aircraft carrier USS Abraham Lincoln and three guided-missile destroyers arrived in January to bolster the number of warships. The world’s largest aircraft carrier, the USS Gerald R. Ford, and four accompanying destroyers later were dispatched from the Caribbean to head to the Middle East and are now in the Mediterranean.

The fleet has added more than 10,000 U.S. troops to the region.

Fighting disrupts commercial air travel

The fighting disrupted air travel in the region. Tens of thousands of travelers around the globe were stranded.

Israel, Qatar, Syria, Iran, Iraq, Kuwait and Bahrain closed their airspace, while Oman’s Muscat International Airport shut down and all flights were restricted over the United Arab Emirates, according to flight tracking website FlightRadar24.

Major airlines based in the Middle East canceled hundreds of flights, while many other travelers were diverted to airports across Europe or flown back to departure airports.

The strikes also could rattle global markets, particularly if Iran makes the Strait of Hormuz unsafe for commercial traffic. A third of worldwide oil exports transported by sea passed through the strait in 2025.

Melanie Lidman in Tel Aviv, Israel, and Josef Federman in Jerusalem contributed.