A long-shuttered and aging Safeway building at 180 El Camino Real in South San Francisco will soon be replaced with a new flagship facility for the grocer, with plans for the undertaking approved by the city this month. 

The new store, which will be open 24 hours, is planned to open mid-2023. The building will also house other retail shops and, unlike the existing structure near the rear of the lot, the new development will be situated near the road with parking and some retail on the first level and the Safeway above.

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