With 20 years of research and development and $1 billion in investment, top officials at South San Francisco biotech company Cytokinetics think a medicine to address heart failure could be available next year.

Robert Blum

Robert Blum

“There are over 5 million people in the United States who have heart failure, and that’s a number that’s growing with the aging of our population. Yet we don’t have a single drug that acts directly on cardiac muscle to address that disease prevalence,” said Robert Blum, president and CEO of Cytokinetics.

It started a program about 20 years ago with human clinical trials beginning to take place in 2005. With more than $1 billion invested and more than 30 completed clinical trials, including one that was the penultimate pivotal trial called Galactic-HF (Global Approach to Lowering Adverse Cardiac Outcomes Through Improving Contractility in Heart Failure), they now have evidence for one of their drug candidates that has had an impact on hospitalizations and rehospitalizations for patients with heart failure, he said.

The name of the medicine is called omecamtiv mecarbil, which is developed purposely for heart failure and directly affects cardiac muscle to safely augment its performance.

“And another benefit of our medicine is that it can be easily added to their current therapy regimens, whereas some other medications have to replace what they’re already on, which makes it more difficult for the patient and the doctor,” Diane Weiser, senior vice president of Corporate Communications and Investor Relations, said.

It will be seeking FDA approval later this year and hopes to have the medicine available to patients next year.

The company focuses on developing medicine for both cardiovascular and neuromuscular diseases of impaired muscle function, and is currently working on several other programs as well to address various diseases.

(650) 344-5200, ext. 105

Recommended for you

(0) comments

Welcome to the discussion.

Keep it Clean. Please avoid obscene, vulgar, lewd, racist or sexually-oriented language.
Don't Threaten. Threats of harming another person will not be tolerated.
Be Truthful. Don't knowingly lie about anyone or anything.
Be Nice. No racism, sexism or any sort of -ism that is degrading to another person.
Be Proactive. Use the 'Report' link on each comment to let us know of abusive posts.
Share with Us. We'd love to hear eyewitness accounts, the history behind an article.

Thank you for visiting the Daily Journal.

Please purchase an Enhanced Subscription to continue reading. To continue, please log in, or sign up for a new account.

We offer one free story view per month. If you register for an account, you will get two additional story views. After those three total views, we ask that you support us with a subscription.

A subscription to our digital content is so much more than just access to our valuable content. It means you’re helping to support a local community institution that has, from its very start, supported the betterment of our society. Thank you very much!