A new U.N. AIDS agency report says the sudden withdrawal of U.S. funding has caused a "systemic shock" to the global effort against AIDS and HIV. Years of American-led investment into AIDS programs has reduced the number of people killed by the disease to the lowest levels in more than three decades. U.S. aid has also bought lifesaving medicines for some of the world's most vulnerable people and rolled out testing and prevention services across Africa. The UNAIDS report released Thursday says if U.S. funding is not replaced it could lead to more than 4 million AIDS-related deaths and 6 million more HIV infections by 2029.

The head of the U.N. AIDS agency says the number of new HIV infections could jump more than six times by 2029 if American support of the biggest AIDS program is dropped. UNAIDS Executive Director Winnie Byanyima warned that millions of people could die and more resistant strains of the disease could emerge. Since President Donald Trump's announcement the U.S. would freeze all foreign assistance for 90 days, Byanyima said officials estimate that by 2029, there could be 8.7 million people newly infected with HIV, a tenfold jump in AIDS-related deaths of 6.3 million and an additional 3.4 million children made orphans.