Iran's supreme leader says the Islamic Republic will protect its nuclear and missile capabilities as a national asset. Ayatollah Mojtaba Khamenei made the statement Thursday, likely drawing a hard line as U.S. President Donald Trump seeks a wider deal to cement the war's shaky three-week ceasefire. Khamenei also said Americans belong "at the bottom" of the Persian Gulf. His remarks come as Iran's oil industry is struggling under a U.S. Navy blockade and as the global economy feels the strain of Iran's chokehold on the Strait of Hormuz. World oil prices surged above $126 a barrel on Thursday. The Trump administration is trying to persuade other nations to help reopen the strait.

Iran is threatening recreational and tourist sites worldwide and insisting it is still building missiles three weeks into an escalating war in the Middle East. The United States is deploying more warships and another 2,500 Marines to the region. As Israeli strikes landed in Tehran, Iran launched more attacks on Israel and energy sites in neighboring Gulf Arab states. With little information coming out of Iran, it was not clear how much damage its forces have suffered in the punishing U.S. and Israeli strikes that began Feb. 28 — or even who was truly in charge of the country. But Iran's attacks are still choking off oil supplies and denting the global economy.

Israel says it has killed two senior Iranian security officials in a major blow to the country's leadership. Iran, which confirmed one killing, fired salvos of missiles and drones Tuesday at its Gulf Arab neighbors and Israel. Israeli Defense Minister Israel Katz announced the deaths of Ali Larijani, the secretary of Iran's Supreme National Security Council, and Gen. Gholam Reza Soleimani, the head of the Revolutionary Guard's all-volunteer Basij force. The Iranian judiciary's news agency, Mizan, confirmed the killing of Soleimani and did not confirm nor deny the death of Larijani. Larijani was considered one of the most powerful figures in the country since Supreme Leader Ayatollah Ali Khamenei was killed on the first day of the war.

Iran's new supreme leader released his first statement since succeeding his late father. Ayatollah Mojtaba Khamenei said Thursday that Iran would keep up its attacks on its Gulf Arab neighbors and use the effective closure of the strategic Strait of Hormuz as leverage against the United States and Israel. Khamenei, 56, who Israel suspects was wounded in the opening salvo of the war, did not appear on camera, as his statement was read by a state TV news anchor. The statement included a vow to avenge those killed in the war, including in a strike on a school that killed over 165 people.

Israel stepped up airstrikes on Iranian missile launchers and a nuclear research site, and Iran retaliated against Israel and across the Gulf region, disrupting energy supplies and travel. As explosions rang out in Tehran and in Lebanon — where Israel said it struck Hezbollah militants — the American embassy in Saudi Arabia came under drone attack. Four days into a war that President Donald Trump suggested would last several weeks but perhaps longer, hundreds of people have been killed in Iran, including people Trump said he had considered as possible future leaders of the country. As the conflict expanded across the region, the State Department said Tuesday it's preparing military and charter flights for Americans who want to leave the Middle East.

The war in the Middle East spiraled further Monday as Israel and the U.S. pounded Iran. U.S. President Donald Trump said the campaign would likely take several weeks. Tehran and its allies hit back against Israel, neighboring Gulf states and targets critical to the world's energy production. The intensity of the attacks, the killing of Iran's supreme leader, and the lack of any apparent exit plan indicated the conflict would not end anytime soon. Israel launched retaliatory attacks in Lebanon after Hezbollah fired missiles at it, and an Israeli military official did not rule out another ground invasion.

Iran has warned Donald Trump not to take any action against the country's Supreme Leader Ayatollah Ali Khamenei, days after the U.S. president called for an end to Khamenei's near 40-year reign. "Trump knows that if any hand of aggression is extended toward our leader, we not only cut that hand but also we will set fire to their world," Gen. Abolfazl Shekarchi, a spokesman for Iran's armed forces, said Tuesday. Trump has drawn two red lines for the Islamic Republic — the killing of peaceful protesters and Tehran conducting mass executions in the wake of the demonstrations. Activists say at least 4,484 people were killed during the protests.